Work

Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome

Year: 1996

Type: article

Abstract: myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects.

Source: Biochemical Journal

DOI: 10.1042/bj3130031

Authors: H. Umesha SHETTY, Harold W. HOLLOWAY, Larisa D. ACEVEDO, Zygmunt GALDZICKI

Institutions: National Institutes of Health, National Institute on Aging

Language: English

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W111593348