Work

Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.

Year: 2014

Type: article

Abstract: evidence suggests that TH is involved in islet β cell proliferation and maturation; however, the signaling pathway(s) connected with this function of TH/TR are not well understood. The purpose of this review is to discuss the current literature that has defined the effects of TH and TRs on pancreatic and islet cell development and function, describe the impact of hyper- and hypothyroidism on whole body metabolism, and highlight future and potential applications of TH in novel therapeutic strategies for diabetes.

Source: PubMed

Authors: Teresa L Mastracci, Carmella Evans-Molina

Institution: Indiana University School of Medicine

Language: English

Topic: Pancreatic function and diabetes

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: George and Frances Ball Foundation, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Award: Mechanisms of Beta Cell Function in Health and Disease