Prevalence and Health Outcomes of Functional Gastrointestinal Symptoms in Infants From Birth to 12 Months of Age
Year: 2015
Type: review
Abstract: OBJECTIVES: The aim of the study was to review published evidence and the opinion of practising clinicians on the prevalence and long-term health consequences of functional gastrointestinal symptoms in infants younger than 12 months. METHODS: PubMed was searched from inception to November 2014 to find articles reporting the prevalence and long-term health outcomes of infantile colic, regurgitation, functional constipation, functional diarrhoea, and dyschezia in infants younger than <12 months. A questionnaire was sent to practising clinicians worldwide, and a group of 15 international experts met to discuss the likely frequency and longer-term consequences of these symptoms. RESULTS: The literature search identified 30 studies reporting the prevalence of infantile colic (2%-73%), 13 that of regurgitation (3%-87%), 8 that of functional constipation (0.05%-39.3%), 2 that of functional diarrhoea (2%-4.1%), and 3 that of dyschezia (0.9%-5.6%). The studies varied in design, populations investigated, and definition of the symptoms. Questionnaires were received from 369 respondents. The experts agreed that the likely prevalences for colic, regurgitation, and functional constipation were 20%, 30%, and 15%, respectively. The limited data in the literature for functional diarrhoea and dyschezia suggest prevalences <10%. Infantile colic may be associated with future health problems in a subset of infants. CONCLUSIONS: Functional gastrointestinal symptoms appear to occur in a significant proportion of infants younger than 12 months and may have an impact on future health outcomes. Prospective collection of data according to agreed criteria is needed to obtain more accurate estimates of the prevalence and consequences of these symptoms.
Authors: Yvan Vandenplas, Abdelhak Abkari, Marc Bellaiche, Marc Benninga, Jean Pierre Chouraqui, FügenÇullu Çokura, Tracy Harb, Badriul Hegar, Carlos Lifschitz, Thomas Ludwig, Mohamed Miqdady, Mauro Batista de Morais, Seksit Osatakul, Silvia Salvatore, Raanan Shamir, Annamaria Staiano, Hania Szajewska, Nikhil Thapar
Institutions: Vrije Universiteit Brussel, Centre Hospitalier Universitaire Ibn Rochd, University of Hassan II Casablanca, Hôpital Robert-Debré, Amsterdam UMC Location University of Amsterdam, Emma Kinderziekenhuis, Centre Hospitalier Universitaire de Grenoble, Istanbul University-Cerrahpaşa, Istanbul University, The University of Queensland, Queensland Children’s Medical Research Institute, University of Indonesia, Hospital Italiano de Buenos Aires, Nutricia Research (Netherlands), Shaikh Khalifa Medical City, Universidade Federal de São Paulo, Prince of Songkla University, University of Insubria, Tel Aviv University, Schneider Children's Medical Center, University of Naples Federico II, Medical University of Warsaw, Great Ormond Street Hospital, University College London
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,780
OpenAlex ID: W1153700157