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Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.

Year: 1970

Type: article

Abstract: Protein deficiency at the time of dosage protects rats against the acute lethal effects of dimethyl nitrosamine, but increases the late carcinogenic actions of the poison. A single dose of 60 mg. dimethyl nitrosamine/kg. leads to the development of kidney cancers in all the surviving rats after 8-11 months. 40 mg./kg. produces tumours in over half of the survivors in 14 months. Induction of liver microsomal hydroxylation enzymes with phenobarbitone does not prevent the carcinogenic effects of dimethyl nitrosamine.

Source: PubMed Central

Authors: A E McLean, P N Magee

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1157758552

FWCI: 2.367

Cites: 6

Cited by: 55

Related to: 10