Work

Dysfunction of the ubiquitin-proteasome system in atherosclerotic cardiovascular disease.

Year: 2015

Type: article

Abstract: The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism and protein quality control in eukaryotic cells. It is involved in a number of biological processes of significance for vascular biology and pathology such as oxidative stress, inflammation, foam cell formation, and apoptosis. This review summarizes both indirect and direct lines of evidence for a role of the UPS in atherosclerosis from the initiation to the progression and complication stage and concludes with a future perspective.

Source: Europe PMC (PubMed Central)

Authors: Feilong Wang, Amir Lerman, Joerg Herrmann

Institution: Mayo Clinic

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Award: The pathophysiological role of the immunoproteasome in atherosclerosis