Routine measurement of haemoglobin A1 at the diabetic outpatient clinic.
Year: 1984
Type: article
Abstract: FOLLOWING the introduction of insulin therapy in 1922 one of the major problems in the long-term management of insulin-dependent diabetes was the lack of a convenient, reliable and objective test of longer term glycaemic control. In the 1960's and early 1970's haemoglobin A, (HbA,, glycosylated haemoglobin) was shown to be elevated, usually, in diabetic patients 1-3 and its biochemical structure was elucidated.4-6 The mid-1970's saw many reports confirming that measurement of HbA, provided an accurate and objective assessment of glycaemic control in the preceding 6 to 8 weeks, a period corresponding to the approximate half-life of the average red blood cell. The vast majority of these studies were either cross-sectional in design 7-10 or, if longitudinal, carried out in the controlled atmosphere of the clinical research centre or hospital ward.", 12 On the basis of this accumulated knowledge, measurement of HbA, has become commonplace in many diabetic outpatient clinics. The purpose of this communication is to report how accurate measurement of HbA, has been successfully introduced to a large diabetic outpatient clinic in such a way that the result is
Source: PubMed Central
Authors: E Byrne, G Savage, J D Merrett, L Kennedy
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W118916208