Plasma levels of Coenzyme Q10 are reduced in critically ill patients as compared to healthy volunteers and correlate with age
Year: 2012
Type: article
Study design: Observational Study
Abstract: The purpose of this study is to investigate Coenzyme Q10 (Q10) levels in critically ill patients as compared to healthy volunteers. Q10 is an essential cofactor for the electron transport chain reactions necessary for the aerobic cellular respiration. Q10 insufficiency, therefore, leads to mitochondrial dysfunction. It also acts as an antioxidant. Oxidative state is prominent in critically ill patients, favoring the production of oxygen-free radicals. A recent study showed reduced Q10 levels in septic shock patients [ 1 ].
Source: Critical Care
DOI: 10.1186/cc10761
Authors: A Coppadoro, L Berra, A Kumar, M Yamada, R Pinciroli, E Bittner, U Schmidt, M Kaneki
Institutions: University of Milano-Bicocca, Massachusetts General Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
OpenAlex ID: W121404425