Work

Presence of the diffuse early antigen of Epstein-Barr virus in lymphomas and lymphoproliferative disorders.

Year: 1992

Type: article

Abstract: The authors recently demonstrated that 40% of Epstein-Barr virus (EBV) associated lymphoproliferative lesions contained lytic as well as latent EBV DNA. To examine more fully the replicative state of EBV in these disorders, the authors studied protein extracts of EBV-associated lymphoid lesions from 13 patients, most of whom were immunosuppressed, for expression of the diffuse early antigen (EA-D) of EBV, by immunoblotting techniques. The reagent used was a mouse monoclonal antibody. Seven of thirteen samples (54%) contained EA-D. These data indicate that in EBV-associated lymphoproliferative lesions, lytic viral replication occurs frequently, manifested by the presence of EBV diffuse early antigen as well as by the presence of lytic EBV DNA replication.

Source: PubMed Central

Authors: B Z Katz, U Saini

Institution: Yale University

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Center for Research Resources

Awards: PATHOGENESIS OF EPSTEIN BARR VIRUS INFECTIONS, BIOMEDICAL RESEARCH SUPPORT, EBV-ASSOCIATED LYMPHOPROLIFERATIONS IN AIDS