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Year: 2012

Type: article

Abstract: Ilya Metchnikoff is widely hailed as the father of modern immunology based on his prescient characterization in the late 19th Century of the macrophage’s roles in phagocytic clearance of infections, tissue development and wound repair [1]. In the ensuing ∼120years, his paradigm of macrophage function has remained largely intact, albeit with a greater appreciation for their functional complexity. In addition to those classical functions identified by Metchnikoff, macrophages can also regulate hematopoiesis, reproduction, vasoregulation, apoptosis, cancer metastasis and lipid metabolism [1,2].

Source: Journal of Hepatology

DOI: 10.1016/j.jhep.2012.04.006

Author: Scott L. Friedman

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,500