Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart.
Year: 1970
Type: article
Abstract: Infective endocarditis continues to be a life-threatening disease despite the availability of antimicrobial agents. ' Even with successful antibiotic treatment, death in intractable heart failure is common because of aortic valve destruction. Furthermore, with the increased scope of cardiac surgical procedures, one of the most serious causes of postoperative failure is infection upon prosthetic valves. This type of endocarditis is very difficult to sterilize with antibiotics, and emboli from sterile thrombi are hazardous. ' Endocarditis is also an increasingly common disease among narcotics users. Yet another area of interest is that of the presumed immunologic sequelae of infective endocarditis. Glomerulonephritis in this infection is one of the forms of glomerulonephritis not due to type A Beta hemolytic streptococci. Thus, there are many common clinical problems that might be better understood were there a simple model in small animals suitable for the laboratory study of bacterial endocarditis. Experiments were undertaken in the hope of developing such a model.
Source: PubMed Central
Authors: P K Garrison, L R Freedman
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W126027595