Work

TLR4 +896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis.

Year: 2014

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.

Source: PubMed

Authors: Yingshui Yao, Xiaohua Ren, Lianping He, Jie Li, Yuelong Jin, Weiwei Chang, Chaopin Li

Institutions: Wannan Medical College, Anhui University of Science and Technology

Language: English

Topic: Asthma and respiratory diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W126694200

FWCI: 0.485

Cites: 24

Cited by: 7

Related to: 10