Year: 2004
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: The purpose of this study was to investigate whether melatonin levels in older cohorts within the 'aged' population were significantly lower than in younger 'aged' individuals and hence point to a possible confound in cross-sectional studies which group individuals over 55 in one category. SETTING AND DESIGN: Melatonin levels of 35 North Queensland residents over 55 years of age living in an aged-care facility, a retirement village or the general community were compared across three age groups. METHODS: Subjects were ten 56-65 year olds, eighteen 66-75 year olds and seven over-75 year olds. Information was obtained on sleep, awakening, medical conditions and medications, with subsequent exclusion of those with known medical conditions and/or medications. Melatonin was collected by salivary samples at 2200 hours and concentrations were determined by immunoassay. RESULTS: Mean melatonin levels were significantly lower (p=.03) in the 'oldest' (over 75 yrs) group compared to the 'youngest' (56-65 yrs) group. MAIN FINDINGS: The results of this preliminary study indicate that within the older population, melatonin levels appear to decline significantly with age. CONCLUSIONS: Future studies of melatonin and ageing may benefit from a longitudinal approach, with older subjects sampled across time.
Source: PubMed
Authors: Deborah Graham, Angus McLachlan
Institution: James Cook University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W127668278