Work

The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease.

Year: 2008

Type: review

Abstract: The endoplasmic reticulum (ER) has emerged as a key to understanding the development and consequences of hepatic fat accumulation in nonalcoholic fatty liver disease (NAFLD). An essential function of this organelle is the proper assembly of proteins that are destined for intracellular organelles and the cell surface. Recent evidence suggests that chemical chaperones that enhance the functional capacity of the ER improve liver function in obesity and NAFLD. These chaperones may therefore provide a novel potential therapeutic strategy in NAFLD.

Source: PubMed

Authors: Christopher L Gentile, Michael J Pagliassotti

Institution: Colorado State University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Obesity and Hepatic Steatosis, Institutional Training Program in Nutrition