Work

Differential Regulation of Ceruloplasmin Isoforms Expression in Macrophages and Hepatocytes

Year: 2011

Type: conference-paper

Abstract: Ceruloplasmin (Cp) is a multicopper oxidase implicated in iron (Fe) metabolism and protection against free radical−driven cell injury [1]. Through oxidation of Fe (II) to Fe (III), Cp assists the sole identified mammalian iron exporter ferroportin (Fpn) for transporting iron out from the cells 2-3]. Cp can be expressed as a soluble secreted protein (sCp) or as a membrane GPI−anchored protein (GPI−Cp) as a result of alternative splicing [4-5]. sCp is abundant in serum and is known to be mostly expressed by hepatocytes while GPI−Cp has been shown to be mostly expressed in astrocytes, leptomeningeal cells, and sertoli cells [1]. Previously, we reported the mRNA expression

Source: Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Authors: Liliana Marques, A Auriac, Alexandra Willemetz, João Banha, Beatriz de Carvalho Farias Lima da Silva, François Canonne‐Hergaux, Luciana Costa

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Fundação para a Ciência e a Tecnologia

Award: CROSSTALK BETWEEN IRON HOMEOSTASIS AND IMMUNE SYSTEM: STUDY OF CERULOPLASMIN AND FERROPORTIN IN HUMAN MONONUCLEAR CELLS

OpenAlex ID: W130307457

FWCI:

Cites: 6

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Related to: 10