Year: 1990
Type: article
Abstract: FK 506 is a macrolide with potent immunosuppressive effects. Its immunosuppressive property has been documented in both in vitro1 lymphocyte proliferation studies and in vivo studies. FK 506 treatment significantly prolongs graft survival in rats receiving heterotopic heart transplants, dogs receiving kidneys or livers, and baboons receiving kidney transplants.2 Currently, FK 506 is undergoing clinical trials at the University of Pittsburgh. This document provides a summary of the biopharmaceutical aspects and the pharmacokinetics of the drug in animals and humans.
Source: PubMed
Authors: R Venkataramanan, A Jain, E Cadoff, V Warty, K Iwasaki, K Nagase, A Krajack, O Imventarza, S Todo, J J Fung
Institution: University of Pittsburgh
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W130797701