Stromal Cell-derived Factor (SDF-1 β) Gene Single Nucleotide Polymorphism at Position G801A is Associated with Type 2 Diabetes Mellitus in a South Indian Population
Year: 2013
Type: article
Study design: Observational Study
Abstract: In this case-control study, we investigated the association of G801A single nucleotide poly morphis ms (SNPs) in the SDF-1β gene (SDF-1β 3'A) with type 2 diabetes (T2DM ) in a south Indian population. In this assessment, peripheral blood samples were collected fro m 150 T2DM patients and 150 healthy controls who attended our tertiary care hospital in Chennai, India. Peripheral b lood genomic DNA was extracted and subjected to PCR-RFLP, to examine SDF-1β gene polymorphis m. Our results showed that the genotype frequency of GG was significantly associated with T2DM when compared to healthy controls (P <0.001). Interestingly, our results also showed that SDF-1 G allele to be risk allele (1.238 (0.899-1.706)) and A to be the protective allele fo r T2DM at least in our south Indian population. Based on the results of this study, we conclude that SDF-1β 3'A poly morphis m to play a role in the pathogenesis of T2DM.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W13097937