Does effective antihypertensive therapy partially "cure" hypertension?
Year: 1985
Type: article
Abstract: The elevated blood pressure of patients with essential hypertension can be considered to result from the interaction of three components: 1) A genetic propensity to hypertension. 2) Environmental factors which interact with the genetic propensity to produce hypertension. This paper will assume that obesity and electrolyte intake are the major environmental factors producing hypertension. 3) Perpetuating (or multiplicative) factors which produce more hypertension than occurs from the initial combination of genetic and environmental factors. In this paper, we wish to propose that the last two factors may be substantially modified. As a consequence of the modification of the environmental factors and the multiplicative changes, we consider some hypertensive patients to be cured. DISH (Dietary Intervention Study in Hypertension) provides the major piece of evidence on which this suggestion is based (1). DISH was a multi-center study of the ability of dietary change to prevent recurrence of hypertension in a long-treated population in which antihypertensive therapy was discontinued. DISH was a collaborative study by investigators from the University of Mississippi School of Medicine, the University of Alabama School of Medicine, the Albert Einstein College of Medicine, and the University of Texas School of Public Health. The first three institutions were clinical centers
Source: PubMed Central
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W131377476