Year: 2006
Type: article
Study design: Observational Study
Abstract: i a l l y BNP a n d c a r d i a c f u n c t i o n .To a s s e s s t h e c l i n i c a l s i g n i f i c a n c e o f HR, we e x a mi n e d 1 2 6 p a t i e n t s wi t h u n t r e a t e d h y p e r t e n s i o n( 7 0 me n a n d 5 6 wo me n;me a n a g e , 5 8 . 2 ±1 0 .8 y e a r s ;s y s t o l i c p r e s s u r e 1 6 5 .0 ±1 5 . 1 mmHg;d i a s t o l i c p r e s s u r e , 9 9 .7 ±9 . 2 mmHg ) .Th e s e p a t i e n t s we r e d i v i d e d i n t o 3 g r o u p s o n t h e b a s i s o f HR:l o w HR ( HR＜7 5 b p m ;n＝5 7;me a n HR,6 5 .6 ±5 .6 b p m);mo d e r a t e HR ( HR,7 5 -8 5 b p m ;n＝4 1;me a n HR,7 9 . 1 ±2 .7 b p m);a n d h i g h HR ( HR＞8 5 b p m ;n＝2 8; me a n HR,9 4 .5 ±9 .9 b p m.I n t h e h i g h HR g r o u p ,s e v e r a l v a r i a b l e s s h o we d mo r e c l i n i c a l d i s a d v a n t a g e c o mp a r e d wi t h o t h e r g r o u p s ,s u c h a s h i g h e r BNP,n o r a d r e n a l i n e ,a n d l o we r e j e c t i o n f r a c t i o n o n e c h o c a r d i o g r a p h y .Th e n u mb e r o f p a t i e n t s wi t h a me t a b o l i c s y n d r o mel i k e d i s o r d e r wa s h i g h e r i n t h e h i g h HR g r o u p ( 3 8 .7 %)t h a n i n t h e mo d e r a t e HR g r o u p ( 3 5 .4 8 %)o r t h e l o w HR g r o u p( 2 5 .8 %) .I n a l l p a t i e n t s , HR wa s p o s i t i v e l y c o r r e l a t e d wi t h l e v e l s o f BNP ( r ＝0 . 2 8 1 , p ＝0 .0 0 1 5 ) , n o r a d r e n a l i n e( r ＝0 .3 3 7 , p ＝0 .0 0 2 0 ) , a n d u r i c a c i d( r ＝ 0 . 2 7 5 , p ＝0 .0 3 6 1 ) .Th e g r o u p s d i d n o t d i f f e r s i g n i f i c a n t l y i n a g e , d i a s t o l i c f u
Institution: Jikei University School of Medicine
Language: Japanese
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W132328657
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