Work

BAR proteins in cancer and blood disorders.

Year: 2012

Type: article

Abstract: Remodeling of the membrane and cytoskeleton is involved in a wide range of normal and pathologic cellular function. These are complex, highly-coordinated biochemical and biophysical processes involving dozens of proteins. Serving as a scaffold for a variety of proteins and possessing a domain that interacts with plasma membranes, the BAR family of proteins contribute to a range of cellular functions characterized by membrane and cytoskeletal remodeling. There are several subgroups of BAR proteins: BAR, N-BAR, I-BAR, and F-BAR. They differ in their ability to induce angles of membrane curvature and in their recruitment of effector proteins. Evidence is accumulating that BAR proteins contribute to cancer cell invasion, T cell trafficking, phagocytosis, and platelet production. In this review, we discuss the physiological function of BAR proteins and discuss how they contribute to blood and cancer disorders.

Source: Europe PMC (PubMed Central)

Authors: Yolande Chen, Jorie Aardema, Ashish Misra, Seth J Corey

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: Scaffolding Proteins in Macrophage Phagocytosis, The F-BAR protein CIP4 in WAS-dependent thrombocytopenia

OpenAlex ID: W133160206

FWCI: 0.607

Cites: 1

Cited by: 13

Related to: 10