Work

Attomole detection of isotope-labeled compounds in chemical defense research

Year: 1996

Type: conference-paper

Abstract: AMS detects 14C at zeptomole to femtomole sensitivities. We detected the effect of ChE-blocking pyridostigmine bromide on the CNS uptake of a pyrethroid insecticide at scaled human-equivalent exposures in rats. Significant blood to brain protection from permethrin dosed at 5mg/kg is seen in the CNS of rats receiving pyridostigmine bromide pretreatments in chow at 2mg/kg/day. The synergy of these compounds was suggested as a precursor to some symptoms of `Gulf War Syndrome`.

Source: University of North Texas Digital Library (University of North Texas)

Authors: John S. Vogel, Bruce A. Buchholz, Norma H. Pawley, R.E. Mauthe, Karen H. Dingley, Kenneth W. Turteltaub

Language: English

Topic: Pesticide Exposure and Toxicity

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Energy, National Physical Science Consortium, University of California, Riverside, University of California, Davis, Lawrence Livermore National Laboratory

Awards: G1101028137, G1702950523, G3177268909, G6445123630

OpenAlex ID: W135484920

FWCI:

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