Olfactory Bulbectomized Rat, a model for what?
Year: 2014
Type: dissertation
Abstract: The olfactory bulbectomized rat has been used primarily as an animal model for the detection of anti-\ndepressive properties of new chemical entities and their assessment against the currently available anti-\ndepressants. This is mainly due to the fact that the chronic efficacy of anti-depressants and not the \n\nacute efficacy is detectable using the model which resembles the efficacy of such drugs in humans. This \n\nreview covers the chronological process that led to this use of this animal model, revises the logical \n\nreasons that justify that use and suggests other diseases the OBX rat can be used as a model for, such as \n\ncertain neurodegenerative disorders and traumatic brain injury. A special consideration is also included \n\nfor the “golden hour” meaning the chemical changes in the brain which occur in the first hour after the \n\ninitial impact of traumatic brain injury, during which medical intervention has the highest potential of \n\ndecreasing the permanent damage. If used as soon as the surgery is complete, the OBX rat could be \n\nevaluated as a model for neuroprotective drugs.
Author: J.F. El Hebieshy
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W137974972