Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium
Year: 2015
Type: article
Abstract: Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend <0.001). Although limited by the retrospective nature of the study and the limited ability to assess risks of mouthwash use in nonusers of tobacco and alcohol, this large investigation shows potential risks for head and neck cancer subsites and in long-term and frequent users of mouthwash. This pooled analysis provides the most precise estimate of the association between mouthwash use and head and neck cancer.
Authors: Paolo Boffetta, Richard B. Hayes, Samantha Sartori, Yuan-Chin A. Lee, Joshua Muscat, Andrew Olshan, Deborah M. Winn, Xavier Castellsagué, Zuo-Feng Zhang, Hal Morgenstern, Chu Chen, Stephen M. Schwartz, Thomas L. Vaughan, Victor Wunsch-Filho, Mark Purdue, Sergio Koifman, Maria P. Curado, Marta Vilensky, Maura Gillison, Leticia Fernandez, Ana Menezes, Alexander W. Daudt, Stimson Schantz, Guopei Yu, Gypsyamber D’Souza, Robert I. Haddad, Carlo La Vecchia, Mia Hashibe
Institutions: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York University, University of Utah, Huntsman Cancer Institute, Pennsylvania State University, University of North Carolina at Chapel Hill, National Cancer Institute, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University of California, Los Angeles, University of Michigan, Fred Hutch Cancer Center, Universidade de São Paulo, Fundação Oswaldo Cruz, International Prevention Research Institute, Universidad de Buenos Aires, Johns Hopkins University, Instituto de Oncología y Radiobiología, Universidade Federal de Pelotas, Hospital de Clínicas de Porto Alegre, New York Eye and Ear Infirmary, Peking University, Harvard University, Dana-Farber Cancer Institute, University of Milan
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCER, Molecular Epidemiology Cancer Training Program, TOBACCO AND CANCER RISK--DOSE, METABOLISM AND GENETICS, Oral HPV Infection in HIV-Infected Men and Women, The UGT2A and 3A metabolizing enzymes and tobacco-related cancer risk, UCLA SPORE IN LUNG CANCER, LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS, ORAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, &IMMUNOLOGY, Epidemiology of protein glutathiolation, Molecular Epidemiology and Gene-Environment Interaction, International Head and Neck Cancer Consortium, MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERS, Pooled Analyses of SNPs and Risk of Head & Neck Cancer, UNC Center for Environmental Health and Susceptibility
OpenAlex ID: W1413291894