Enhancement of the immune response in rabbits by administration of immunoglobulin-G.
Year: 1970
Type: article
Abstract: Enhancement of the antibody response of rabbits to diphtheria toxoid (DT) and bovine serum albumin (BSA) was obtained by administration of IgG from either normal rabbit serum or serum of rabbits treated with Freund's complete adjuvant (FCA). It was shown that the concentration of IgG was greater in the serum of adjuvant treated rabbits than in normal rabbit serum, and that, in the case of BSA, greater enhancement of antibody formation was provided by the IgG derived from a volume of serum from adjuvant-treated rabbits than by the IgG from an equal volume of normal serum. Interpretation of these results within the framework of the natural selection model of antibody production provides a mechanism of action for Freund's adjuvant. Attempts to specifically remove the adjuvant effect of IgG for BSA by absorption with insoluble, polymerized BSA were unsuccessful. However, specific anti-BSA antibody was recovered from normal IgG by elution from the immunosorbent. This material is thought to represent natural antibody of the IgG class.
Source: PubMed Central
Authors: D L Dawe, W L Myers, D Segre
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W141780206