Investigating regulatory T cells by single cell RNA-sequencing
Year: 2014
Type: other
Abstract: OBJECTIVES Single-cell transcriptomics is an emergent and powerful approach to understand the complexity inherent in many cell populations. Its relevance has been growing as increasing evidence supports the existence of marked heterogeneity within cell populations previously considered as homogeneous. This is particularly important for many immune cell types, where single cell RNA-sequencing has the potential to provide profound new insights into subpopulation structure. This project focuses on a particular immune lineage Regulatory T (Treg) cells – which play a central role in peripheral tolerance to selfand non-self-antigens. By single-cell mRNA sequencing of Treg cells, we intend to address their remarkable gene expression plasticity, determine Treg identity, define subsets, and investigate their functions, surface markers and key features. Results from this work will provide a more comprehensive overview of how immune homeostasis is regulated.
Institution: European Bioinformatics Institute
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W142547460