Work

Ufd2a Isoforms with VSP/p97 and its IBMPFD Mutants

Year: 2011

Type: article

Abstract: Using the Yeast2Hybrid system, the binding affinities between Ufd2a variants and VCP/p97 mutants were analyzed. Several VCP/p97 mutants are associated with Inclusion body myositis in association of Paget's disease of the bone and fronto temperal dementia (IMBPFD). It was found that Ufd2a bound strongest to the VCP disease causing mutant A232E. It was also determined that the muscle specific isoform of Ufd2a, Ufd2a III, did not interact with VCP/p97.

Source: Digital Commons (Providence College)

Author: Amanda St. Germain

Institution: Rhode Island College

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, U.S. Department of Agriculture, National Institutes of Health, National Center for Research Resources, Office of Experimental Program to Stimulate Competitive Research

OpenAlex ID: W142883991

FWCI:

Cites: 3

Cited by:

Related to: 10