Circulating immune complexes in atherosclerotic vascular disease
Year: 2001
Type: dissertation
Study design: Observational Study
Abstract: We have investigated the association of the humoral immune factors\ncirculating immune complexes (CICs) and autoantibodies against\ncardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic\nvascular diseases.\n\nIn a prospective nested case-control study, in which healthy 50-year-old\nmen were followed for 20 years, the prevalence of elevated CICs and the\nconcentration of CICs were higher in men who developed myocardial\ninfarction. (MI) than in those who remained healthy. CICs was a strong\nand independent risk factor. There was a positive relation between the\nlevels of CICs and IgG-aCL in men who developed Nil. The level of IgG-aCL\nand the prevalence of elevated IgG- and IgM-aCL were higher in those who\ndeveloped MI and had CICs than in those without CICs. Among men\nhomozygous for C4 null alleles, those who developed MI had higher\nconcentrations of CICs than did those who remained healthy.\n\nIn a five-year prospective study, CICs and antibodies against oxLDL were\nassociated with progression of coronary atherosclerosis in young\ndyshpoproteinemic men suffering from coronary artery disease.\n\nIn 18% of patients who had survived a premature MI, CICs were present in\nhigh concentrations many years after the event. Antibodies of the IgG\nisotype predominated in CICs. Half of the patients with persistent high\nCICs had alimentary proteins in the immune complexes. A rise in CICs,\nsigns of activation of the complement cascade, and a rise in plasma\nconcentrations of vonWillebrand factor antigen were evident within one\nweek in four young patients subjected to a 2-week elimination diet\nfollowed by challenge with the alimentary antigen in question.\n\nElevated levels of CICs were present in patients with premature\nperipheral atherosclerosis and null alleles of C4A (C4A*QO) enhanced the\npropensity to ICs formation.\n\nCICs were increased in patients with diabetes, and especially in those\nwith vascular complications. The concentrations of aCL were relatively\nhigher in CICs than in serum. The concentration and prevalence of CICs\nwere increased in patients with C4A*QO. Patients with vascular\ncomplications had more often C4A*QO than C4B*QO.
Source: Figshare
Author: Awder Mustafa
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W144253810