Year: 2015
Type: dissertation
Abstract: MicroRNA control of drug-resistance in haematological malignanciesBy Michael P. Screen miRNAs have been shown to play a role in fundamental cellular processes.They are also involved in drug-resistance mechanisms, which hamper the treatment of many types of cancer, including haematological malignancies.This study sought to uncover mechanisms of miRNA-induced drug-resistance in two haematological malignancies: diffuse large B-cell lymphoma (DLBCL) and multiple myeloma (MM).To this end, profiling of DLBCL and MM-derived cell lines was carried out to identify miRNAs whose levels were altered relative to their respective controls.The expression levels of these miRNAs were then modulated in the cell lines to examine the effect upon cell survival.I would also like to thank all members of the translational control and mechanisms of cell death groups for their help, support and friendship, during the last four years.A special thanks must go; to Emilie Horvilleur (who contributed to some of the initial experiments) Thomas Sbarrato and Lindsay Wilson for sharing their knowledge and the time they took to teach me new techniques in the early days of my PhD; to Xavier Pichon, Amandine Bastide and John Knight for their friendship and advice, not always science-related; to Tuija Poyry, who has supervised me through the final year of my PhD and has given me excellent advice regarding my thesis; and lastly Debs and Jashu without whom nothing in the laboratory would get done.I am very grateful to the friends I have made in the unit for all the great times I've had during my time in Leicester, and to
Author: Michael Screen
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1453859822