Role of Histone Deacetylases in Fungal Phytopathogenesis: A Review
Year: 2014
Type: review
Abstract: Acetylation of lysine is one of the major regulators of function of histone and non-histone proteins of eukaryotic cells, viewed as an avenue for cellular response to environmental, nutritional and behavioural factors. Aberrant protein acetylation as well as inhibition of acetylation or deacetylation has been related to variety of highly dissimilar diseases across species ranging all the way from cancers in humans to fungal diseases in plants. A number of small molecule secondary metabolites and non-ribosomal peptides from fungus as well as several secondary metabolites from plants have been suggested as deacetylation inhibitors. Inhibitory characteristics of a few of these compounds have been explored experimentally in detail and clinical uses have been investigated. For several others, their role in deacetylation inhibition has been suggested and shown in preliminary studies. Several of these inhibitory metabolites play a significant role in fungal phytopathology both as toxins and as metabolites engaged in protection. Present review establishes functions of Zn 2+ -dependent histone deacetylase enzymes of plants and fungi in phytopathology. The connection between metabolites and histone deacetylase enzymes and their reciprocal regulation particularly in relation to fungal invasion and plant resistance is also corroborated. The interaction between metabolites and representatives of different classes of histone deacetylases is reviewed that revealed binding characteristics of fungal cyclic peptides, fungal toxins, and plant secondary metabolites.
Authors: Miroslava Čuperlović‐Culf, Adrian S. Culf
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W146320978