The Role of Interleukin (IL)-22 as a Pro-Inflammatory Cytokine in Systemic Lupus Erythematosus
Year: 2015
Type: article
Study design: Observational Study
Abstract: Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multiple organ damage in addition to amounts of autoantibodies generated by excessively activated B cells, abnormal T cell subsets and related cytokines are also involved in the pathophysiology of SLE. Interleukin (IL)-22 is a cytokine that is important for the modulation of tissue responses during inflammation. IL-22 has both pro-inflammatory and tissue-protective properties, therefore this study aimed to assess the role of IL-22 levels in plasma of patients with SLE and compare it with normal controls. Also to correlate plasma levels of IL-22 with disease activity using systemic lupus erythematosus score (SLEDAI) in SLE patients. Subjects and Methods: Thirty five SLE patients (Group I) were subjected to full history taking and clinical examination, assessment of SLEDAI, laboratory investigations in the form of serological markers for systemic lupus activity, including anti-double stranded deoxyribonucleic acid (anti-ds DNA), anti-nuclear antibodies (ANA), and autoimmune profile complement components C3 and C4 levels, CBC, ESR, ALT, AST, blood urea nitrogen (BUN), serum and urinary creatinine and urinary protein, in addition to 40 age and sex matched healthy controls (Group II). Plasma IL-22 level using ELISA technique was done to all participants. Results: The plasma levels of IL-22 in SLE patients were significantly higher than normal controls with evidence of positive correlation between IL-22 levels and SLEDAI score. Conclusively, it could be suggested that the IL-22 may be implicated in the pathogenesis of SLE disease.
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1464320711