The reconstitution of immunocompetence by GM-CSF or IFN[gamma] after pharmacological suppression
Year: 2000
Type: dissertation
Abstract: While immunosuppression is required to prevent graft rejection in transplantation, it increases the risk of infection. We investigated in mice immunosuppressed by different immunosuppressives (cyclosporin A, dexamethasone, tacrolimus and sirolimus), whether the innate immune system can be reactivated by granulocyte-macrophage colony stimulating factor (GM-CSF) or interferon-gamma (IFNg). Both study drugs reconstituted the suppressed macrophage response ex vivo and in vivo, while the IL-2 and IFNg response of T-cells remained silenced. Mice, immunosuppressed by cyclosporin A or dexamethasone survived a lethal Salmonella typhimurium infection when pretreated with GM-CSF or IFNg without inducing skin graft rejection after allotransplantation. We propose to consider GM-CSF or IFNg for a therapeutic improvement of the resistance of transplant patients to infections.
Source: KOPS (University of Konstanz)
Author: Simone Kühnle
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W147869234