T-Even Bacteriophage-Tolerant Mutants of Escherichia coli B II. Nucleic Acid Metabolism
Year: 1971
Type: article
Abstract: T-even bacteriophage-tolerant mutants are strains of Escherichia coli which can adsorb T-even phages but cannot support the growth of infective virus. Under some conditions, the infected cells are not killed. Mutant cells infected by phage T6 are able to carry out several metabolic functions associated with normal virus development, including arrest of bacterial nucleic acid and protein synthesis, incorporation of isotopic precursors into viral nucleic acids and proteins, synthesis of early enzymes of deoxyribonucleic acid (DNA) metabolism, formation of rapidly sedimenting DNA intermediates, and formation of normal levels of early and late messenger ribonucleic acid species. Phage are unable to mutate to forms capable of growth on these mutants. The nature of the biochemical alteration leading to tolerance is still unknown.
Source: Journal of Virology
Institution: University of Arizona
Language: English
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1479899503