Work

Comparative pharmacokinetics of cyclosporine and NVa2-cyclosporine in dogs.

Year: 1987

Type: article

Abstract: NVA2-Cyclosporine (NVa2-CsA) is a structural analogue of cyclosporine (CsA) with marked immunosuppressive activity.1–3 NVa2-CsA appears to be less nephrotoxic when compared with CsA in rodent models.4 During efficacy studies in canine orthotopic liver allografts, equal doses of NVa2-CsA and CsA produced significantly different blood concentrations. This observation prompted us to evaluate the comparative pharmacokinetics of NVa2-CsA and CsA in dogs.

Source: PubMed

Authors: R Venkataramanan, S Todo, I Zaghloul, S Lynch, I Kam, R J Ptachcinski, G J Burckart, T E Starzl

Institution: University of Pittsburgh

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1481451366

FWCI: 0.432

Cites: 5

Cited by: 5

Related to: 10