Work

A practical radiosynthesis of a tritium‐labelled fluorocombretastatin

Year: 2012

Type: article

Abstract: Zybrestat (combretastatin A‐4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent, and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat. Copyright © 2012 John Wiley & Sons, Ltd.

Source: Journal of Labelled Compounds and Radiopharmaceuticals

DOI: 10.1002/jlcr.2939

Authors: John A. Hadfield, Nicholas Hirst, Keira Gaukroger, Nicholas J. Lawrence, Alan T. McGown

Institutions: Kidscan Children's Cancer Research, University of Salford, Cancer Research UK Manchester Institute, Moffitt Cancer Center

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1481517641

FWCI:

Cites: 13

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Related to: 10