Year: 2009
Type: review
Abstract: The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
Source: Aging
Institutions: University of Southampton, Southampton General Hospital
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W1481811876