Work

SHP-2 tyrosine phosphatase in human diseases.

Year: 2009

Type: article

Abstract: SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease. SHP-2 has been clearly demonstrated to be an important molecule in various cytoplasmic signal transduction pathways. In addition, emerging evidence indicates that SHP-2 may function in the nucleus and in the mitochondria. However, the signaling mechanisms of SHP-2 are not completely understood. Interestingly, genetic mutations in SHP-2 that either enhance or inactivate its catalytic activity have been identified in human diseases with overlapping phenotypes. In light of this hint given by nature, new cell and animal models now provide the opportunity to uncover how this molecule functions in multiple cellular processes, and more importantly, how its known mutations induce human diseases.

Source: PubMed

Authors: Hong Zheng, Shawn Alter, Cheng-Kui Qu

Institutions: Case Comprehensive Cancer Center, Case Western Reserve University

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: SHP-2 Inhibitors as Potential Therapeutic Agents for JMML and Noonan Syndrome, Protein Tyrosine Phosphatase and Hematopoietic Cell Regulation