Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND: In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women. Recurrences frequently occur, and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed. METHODS: Cigarette smoking behavior and body mass index were investigated at diagnosis for associations with bladder cancer recurrence in a population-based study of 726 patients with bladder cancer in New Hampshire, United States. Patients diagnosed with non-muscle invasive urothelial cell carcinoma were followed to ascertain long-term prognosis. Analysis of time to recurrence was performed using multivariate Cox regression models. RESULTS: Smokers experienced shorter time to recurrence (continuing smoker hazard ratio [HR] = 1.51, 95% confidence interval [CI] = 1.08-2.13). Although being overweight (body mass index > 24.9 kg/m(2) ) at diagnosis was not a strong independent factor (HR = 1.33, 95% CI = 0.94-1.89), among continuing smokers, being overweight more than doubled the risk of recurrence compared to smokers of normal weight (HR = 2.67, 95% CI = 1.14-6.28). CONCLUSIONS: These observational results suggest that adiposity is a risk factor for bladder cancer recurrence, particularly among tobacco users. Future intervention studies are warranted to evaluate whether both smoking cessation and weight reduction strategies reduce bladder tumor recurrences.
Source: Cancer
DOI: 10.1002/cncr.28394
Institutions: Dartmouth College, Brown University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Bladder Cancer Prognostic Indicators, G1069150658, G1244673131, G1318433929, Comprehensive Assessment of Bladder Cancer Genetic Susceptibility, Molecular Epidemiology of Non-Melanoma Skin Cancer, G1769572317, G2299545052, G2429810426, Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury, G3084366702, MicroRNA dysregulation and bladder cancer prognosis, SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE, Non-Melanoma Skin Cancer in New Hampshire, Harvard Chan School NIEHS Center for Environmental Health, Quantitative Biology Research Institute, G723185991, Quantitative Biology Research Institute, G9000127527, Cellular and Molecular Mechanisms of Lung Disease
OpenAlex ID: W1482328974