Year: 2013
Type: review
Abstract: With diabetes mellitus becoming an important public health concern, insulin-delivery systems are attracting increasing interest from both scientific and technological researchers. This feature article covers the present state-of-the-art glucose-responsive insulin-delivery system (denoted as GRIDS), based on responsive polymer materials, a promising system for self-regulated insulin delivery. Three types of GRIDS are discussed, based on different fundamental mechanisms of glucose-recognition, with: a) glucose enzyme, b) glucose binding protein, and c) synthetic boronic acid as the glucose-sensitive component. At the end, a personal perspective on the major issues yet to be worked out in future research is provided.
Source: Macromolecular Bioscience
Authors: Weitai Wu, Shuiqin Zhou
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1483026890