Year: 2002
Type: dissertation
Abstract: Research in computational protein design has produced a number of algorithms that are empirically effective for selecting amino acid sequences that fold to desired protein structures.In comparison, the problem of designing proteins for desired functionality (e.g.binding specificity) has not been as well explored.This M. Eng.thesis aims to develop software for this purpose.Algorithms for sequence selection have been adapted from known algorithms for designing fold stability.The result of the thesis is a computational toolkit for biologists who wish to reengineer the structure and properties of protein folds or interfaces.
Author: Daniel J. Park
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1483125348