Work

A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

Year: 1979

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: 1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar antihypertensive effects. 3 The overall incidence of side-effects was similar with atenolol, metoprolol and pindolol but was slightly less with labetalol. Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol. 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods.

Source: British Journal of Clinical Pharmacology

DOI: 10.1111/j.1365-2125.1979.tb04774.x

Authors: JJ McNeil, WJ Louis

Institutions: The University of Melbourne, Austin Hospital, The Alfred Hospital, Alfred Health

Language: English

Topic: Blood Pressure and Hypertension Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1483141901

FWCI: 6.519

Cites: 11

Cited by: 55

Related to: 10