Coenzyme Q10 and spinocerebellar ataxias
Year: 2014
Type: article
Study design: Observational Study
Abstract: The aim of this study was to investigate the association between drug exposure and disease severity in SCA types 1, 2, 3 and 6. The Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) enrolled 319 participants with SCA1, 2, 3, and 6 from 12 medical centers in the United States and repeatedly measured clinical severity by the Scale for Assessment and Rating of Ataxia (SARA), the Unified Huntington's Disease Rating Scale part IV (UHDRS-IV), and the 9-item Patient Health Questionnaire during July 2009 to May 2012. We employed generalized estimating equations in regression models to study the longitudinal effects of coenzyme Q10 (CoQ10), statin, and vitamin E on clinical severity of ataxia after adjusting for age, sex, and pathological CAG repeat number. Cross-sectionally, exposure to CoQ10 was associated with lower SARA and higher UHDRS-IV scores in SCA1 and 3. No association was found between statins, vitamin E, and clinical outcome. Longitudinally, CoQ10, statins, and vitamin E did not change the rates of clinical deterioration indexed by SARA and UHDRS-IV scores within 2 years. CoQ10 is associated with better clinical outcome in SCA1 and 3. These drug exposures did not appear to influence clinical progression within 2 years. Further studies are warranted to confirm the association.
Source: Movement Disorders
DOI: 10.1002/mds.26088
Authors: Raymond Y. Lo, Karla P. Figueroa, Stefan M. Pulst, Chi‐Ying Lin, Susan Perlman, George Wilmot, Christopher Gomez, Jeremy Schmahmann, Henry Paulson, Vikram G. Shakkottai, Sarah Ying, Theresa Zesiewicz, Khalaf Bushara, Michael Geschwind, Guangbin Xia, S.H. Subramony, Tetsuo Ashizawa, Sheng‐Han Kuo
Institutions: Tzu Chi University, Buddhist Tzu Chi General Hospital, University of Utah, Columbia University, University of California, Los Angeles, Emory University, University of Chicago, Harvard University, Massachusetts General Hospital, University of Michigan, Johns Hopkins University, University of South Florida, University of Minnesota, University of California, San Francisco, University of Florida Health, University of Florida
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1483324588