Work

Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function

Year: 1998

Type: article

Abstract: We have cloned and sequenced the complete protein-coding region of the pig PIT-1 gene. The pig PIT-1 gene is highly similar to the PIT-1 gene in other species (human, rodent, cattle). We also found some alternative forms of the pig PIT-1 gene. We have analyzed the protein function of the pig PIT-1 genes and one of its alternative forms; D3PIT-1. The functional studies showed that the pig PIT-1 protein can function normally at growth hormone (GH) and prolactin (PRL), whereas the pig D3PIT-1 protein cannot. These results imply that the pig PIT-1 gene is important in pig growth through regulation of GH and PRL gene expression, whereas its alternative forms might play different roles on PIT-1 target genes.

Source: Iowa State University Digital Repository (Iowa State University)

Authors: T.‐P. Yu, H. Sunny Sun, Max F. Rothschild, Christopher K. Tuggle

Institution: Iowa State University

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Zero hunger

Open Access status: green

Funder: U.S. Department of Agriculture

OpenAlex ID: W1483643294

FWCI:

Cites: 1

Cited by:

Related to: 9