Simultaneous registration and activation detection: overcoming activation-induced registration errors in functional mri
Year: 2003
Type: dissertation
Abstract: In the processing of functional magnetic resonance imaging (fMRI) data, motion correction is typically performed before activation detection.However, on high-field MR scanners (3 T and higher), the strength of the blood oxygen level dependent (BOLD) signal can cause registration algorithms to produce motion estimates that have stimulus-correlated errors.Motion compensation using these biased motion estimates can result in both false-positive and false-negative regions of activation.By formulating the registration and activation detection problems into a single leastsquares problem, both the motion estimates and activation map can be solved for simultaneously.However, the solution is not unique and an additional constraint is used to find a solution that is appropriate.This constrained optimization problem can be solved efficiently, and two equivalent methods are proposed and demonstrated on both simulated and in vivo datasets.
Source: Summit (Simon Fraser University)
Authors: M. Stella Atkins, Jeffrey John Orchard
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1483786659