Work

Pregnane X receptor‐ and CYP3A4‐humanized mouse models and their applications

Year: 2010

Type: review

Abstract: Pregnane X receptor (PXR) is a pivotal nuclear receptor modulating xenobiotic metabolism primarily through its regulation of CYP3A4, the most important enzyme involved in drug metabolism in humans. Due to the marked species differences in ligand recognition by PXR, PXR-humanized (hPXR) mice, and mice expressing human PXR and CYP3A4 (Tg3A4/hPXR) were established. hPXR and Tg3A4/hPXR mice are valuable models for investigating the role of PXR in xenobiotic metabolism and toxicity, in lipid, bile acid and steroid hormone homeostasis, and in the control of inflammation.

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.2010.01129.x

Authors: Jie Cheng, Xiaochao Ma, Frank J Gonzalez

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research, University of Kansas Medical Center

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute