Year: 2010
Type: dissertation
Abstract: 208-5 (pdf)Two types of antigen-presenting cells (APCs), macrophages and dendritic cells (DCs), function at the interface of innate and adaptive immunity.Through recognition of conserved microbial patterns, they are able to detect the invading pathogens.This leads to activation of signal transduction pathways that in turn induce gene expression of various molecules required for immune responses and eventually pathogen clearance.Cytokines are among the genes induced upon detection of microbes.They play an important role in regulating host immune responses during microbial infection.Chemotactic cytokines, chemokines, are involved in migratory events of immune cells.Cytokines also promote the differentiation of distinct T cell responses.Because of the multiple roles of cytokines in the immune system, the cytokine network needs to be tightly regulated.In this work, the induction of innate immune responses was studied using human primary macrophages or DCs as cell models.Salmonella enterica serovar Typhimurium served as a model for an intracellular bacterium, whereas Sendai virus was used in virus experiments.The starting point of this study was that DCs of mouse origin had recently been characterized as host cells for Salmonella.However, only little was known about the immune responses initiated in Salmonella-infected human DCs.Thus, cellular responses of macrophages and DCs, in particular the pattern of cytokine production, to Salmonella infection were compared. Microbe-induced Innate Immune Responses in HumanDendritic Cells
Source: Työväentutkimus Vuosikirja
Author: Taija E. Pietilä
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1484043940