Work

Diagnosis and treatment of depression and cognitive impairment in late life

Year: 2015

Type: article

Abstract: Cognitive impairment in late-life depression is prevalent, disabling, and heterogeneous. Although mild cognitive impairment in depression does not usually progress to dementia, accurate assessment of cognition is vital to prognosis and treatment planning. For example, executive dysfunction often accompanies late-life depression, influences performance across cognitive domains, and is associated with poor antidepressant treatment outcomes. Here, we review how assessment can capture dysfunction across cognitive domains and discuss cognitive trajectories frequently observed in late-life depression in the context of the neurobiology of this disorder. We also review the efficacy of a sample of interventions tailored to specific cognitive profiles.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/nyas.12669

Authors: Sarah Shizuko Morimoto, Dora Kanellopoulos, Kevin J. Manning, George S. Alexopoulos

Institutions: Weill Cornell Medicine, UConn Health

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Mental Health