Premalignant gastric heterotopic pancreas.
Year: 2008
Type: article
Study design: Case Report
Abstract: Heterotopic pancreas, also known as ectopic pancreas, aberrant pancreas, and pancreatic rest, was first characterized in 1729 by Jean Schultz and refers to ectopic pancreatic tissue that lacks anatomic or vascular connection with the pancreas.1 Heterotopic pancreas is believed to arise during rotation of the foregut, when fragments of the pancreas become separated from the main body and are deposited at ectopic sites.2,3 The two best-known histogenic theories are based on fetal migration of pancreatic cells and on the penetration of immature gastric mucosa inside the submucosa followed by its differentiation into pancreatic tissue.3 Malignant transformation is not common. In this case report, we describe a rare case of pancreatic intraepithelial neoplasia-2 (PanIN-2) found in a gastric heterotopic pancreas. PanIN-2, a mucinous ductal lesion of the pancreas, is believed to represent a precursor lesion for the development of ductal adenocarcinoma.
Source: PubMed Central
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1486596979