Work

To Switch or Not to Switch? Phenotypic switching is sensitive to multiple inputs in a pathogenic fungus

Year: 2009

Type: article

Abstract: Candida albicans is the most commonly isolated human fungal pathogen and uses a diverse repertoire of morphological transitions to aid colonization and infection. In a recent paper we discuss how one of these transitions, the white-to-opaque switch, is affected both by cell stress and by several other conditions that change the rate of cell growth. Based on our findings, we propose that the master regulator of the white-to-opaque switch, WOR1, acts as a sensitive monitor of both intrinsic and environmental conditions.

Source: Communicative & Integrative Biology

DOI: 10.4161/cib.2.6.9487

Authors: Kevin Alby, Richard J. Bennett

Institution: Brown University

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,459

Funders: Burroughs Wellcome Fund, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research