Work

Signalling and pharmacological properties of the P2Y14receptor

Year: 2010

Type: review

Abstract: The P2Y(14) receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators.

Source: Acta Physiologica

DOI: 10.1111/j.1748-1716.2010.02116.x

Authors: T. K. Harden, J. I. Sesma, I. P. Fricks, E. R. Lazarowski

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: P2Y-Purinergic Receptors, Pulmonary Epithelia in Health and Disease, G3367022616, G40790798