Work

Mechanisms of HIV Suppression by Various Microbes in Human Lymphoid Tissue

Year: 2005

Type: article

Abstract: Various pathogens enhance HIV replication and disease progression in coinfected individuals. However, we, and others, have provided examples of microbial interactions that suppress HIV-1 infection both in vivo and ex vivo. Here, we report on the mechanisms of interactions of HIV-1 with several such microbes in the context of ex vivo infected human lymphoid tissue. Blocks of human tonsils maintained ex vivo were coinfected with R5 or X4 HIV-1 and with another microbe, measles virus (MV), vaccinia, herpesvirus 6 (HHV-6), herpesvirus 7 (HHV-7), cytomegalovirus (CMV), or a parasite, Toxoplasma gondii (TG).

Source: Retrovirology

DOI: 10.1186/1742-4690-2-s1-s8

Author: Leonid Margolis

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890