Work

B cells in the aging immune system: time to consider B‐1 cells

Year: 2015

Type: review

Abstract: The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/nyas.12825

Authors: Nichol E. Holodick, Thomas L. Rothstein

Institutions: Feinstein Institute for Medical Research, Hofstra University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute for Health and Care Research, National Institute of Allergy and Infectious Diseases